产品展示
DPOLA/DNA polymerase alphaDNA聚合酶α抗体
点击次数：233发布时间：2012/12/5 13:58:14
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-6166R
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详细内容
货号：BY-6166R
英文名称：Anti-DPOLA/DNA polymerase alpha
中文名称：DNA聚合酶α抗体
其他名称：名DNA polymerase alpha 1 catalytic subunit; DNA polymerase alpha catalytic subunit; DNA polymerase alpha catalytic subunit p180; DNA polymerase alpha p180 subunit; DPOLA_HUMAN; P180; p180 subunit; POLA; POLA1; Polymerase （DNA directed）, alpha 1, catalytic subunit; Polymerase （DNA-directed）, alpha （70kD）.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 161kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb, dog, hrs
产品介绍：Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex （composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 ａnd two primase subunits PRIM1/p49 ａnd PRIM2/p58） is recruited to DNA at the replicative forks via direct interactions with MCM10 ａnd WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading ａnd lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit ａnd subsequently transferred to polymerase delta ａnd polymerase epsilon for processive synthesis on the lagging ａnd leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity ａnd lacks intrinsic 3＇ exonuclease activity for proofreading error, ａnd therefore is not well suited for replicating long complexes.
