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phospho-DOK1(Tyr362)磷酸化D酪氨酸激酶衰减蛋白1抗体
点击次数：234发布时间：2012/12/5 13:59:34
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-5289R
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详细内容
货号：BY-5289R
英文名称：Anti-phospho-DOK1（Tyr362）
中文名称：磷酸化D酪氨酸激酶衰减蛋白1抗体
其他名称：名DOK1; downstream of tyrosine kinase 1; docking protein 1; Docking protein 1; docking protein 1 62kD; DOK 1; P62DOK; pp62; DOK 1; DOK-1; p62DOK1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 62kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, cow, dog
产品介绍：Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia （CML） patients in the chronic phase. It may be a critical substrate for p210（bcr/abl）, a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus ａnd ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 （RasGAP） from CML cells. It has been postulated to play a role in mitogenic signaling.Subunit : Interacts with ABL1 （By similarity）. Interacts with RasGAP ａnd INPP5D/SHIP1. Interacts directly with phosphorylated ITGB3.Subcellular Location : Isoform 1: Cytoplasm. Isoform 3: Cytoplasm, perinuclear region.Tissue Specificity : Expressed in pancreas, heart, leukocyte ａnd spleen. Expressed in both resting ａnd activated peripheral blood T-cells.Similarity : Belongs to the DOK family. Type A subfamily.Contains 1 IRS-type PTB domain.Contains 1 PH domain.
