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phospho-DAXX (Ser517)磷酸化Fas相关死亡结构域蛋白抗体
点击次数：253发布时间：2012/12/5 14:00:22
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-5292R
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详细内容
货号：BY-5292R
英文名称：Anti-phospho-DAXX （Ser517）
中文名称：磷酸化Fas相关死亡结构域蛋白抗体
其他名称：名BING 2; BING2; DAP 6; DAP6; Death associated protein 6; Death domain associated protein 6; EAP 1; EAP1; ETS1 associated protein 1; Fas death domain associated protein; hDaxx; MGC126245; MGC126246.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 82kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Apoptosis, or programmed cell death, occurs during normal cellular differentiation ａnd development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF ａnd Fas ligand of the TNF family through their death domain containing receptors, TNFR1 ａnd Fas. Cell death signals are transduced by death domain （DD） containing adapter molecules ａnd members of the ICE/CED3 protease family. A novel DD containing molecule was recently cloned from mouse, human ａnd monkey ａnd designated Daxx. Daxx is a death domain containing important intermediate in the Fas mediated apoptosis. Daxx binds specifically to the Fas death domain ａnd enhances Fas induced apoptosis ａnd activates the Jun N terminal kinase （JNK） pathway. It is widely expressed in fetal ａnd adult human ａnd mouse tissue, indicating its important function in Fas signaling pathways.
