本公司经销DDC/DOPA Decarboxylase，多巴胺脱羧酶抗体，克隆类型为polyclonal，宿主来源是Rabbit，DDC/DOPA Decarboxylase多巴胺脱羧酶抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0180R
英文名称：Anti-DDC/DOPA Decarboxylase
中文名称：多巴胺脱羧酶抗体
其他名称：名AADC; Aromatic L Amino Acid Decarboxylase; DDC protein; DOPA decarboxylase.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 53kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：DOPA decarboxylase is an enzyme implicated in 2 metabolic pathways, synthesizing 2 important neurotransmitters: dopamine ａnd serotonin which both play key roles in many clinical disorders, including Parkinson＇s disease. Following the hydroxylation of tyrosine to form L dihydroxyphenylalanine （LDOPA）, catalyzed by tyrosine hydroxylase, DDC decarboxylates LDOPA to form dopamine. This neurotransmitter is found in different areas of the brain ａnd is particularly abundant in basal ganglia. Dopamine is also produced by DDC in the sympathetic nervous system ａnd is the precursor of the catecholaminergic hormones, noradrenaline ａnd adrenaline in the adrenal medulla. In the nervous system, tryptophan hydroxylase produces 5 OH tryptophan, which is decarboxylated by DDC, giving rise to serotonin. DDC is a homodimeric, pyridoxal phosphate dependent enzyme.Function : Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine （DOPA） to dopamine, L-5-hydroxytryptophan to serotonin ａnd L-tryptophan to tryptamine.Subunit : Homodimer.DISEASE : Defects in DDC are the cause of aromatic L-amino-acid decarboxylase deficiency （AADCD） [MIM:608643]. AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin ａnd catecholamine deficiency. It causes developmental ａnd psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy ａnd inheritance is autosomal recessive.Similarity : Belongs to the group II decarboxylase family.该抗体主要用于：神经细胞退行性改变-老年滞呆的研究产品图片Antigen: bs-0044P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti- Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.