产品展示
Phospho-p56Dok2(Tyr299)磷酸化D酪氨酸激酶衰减蛋白2抗体
点击次数：197发布时间：2012/12/5 14:10:05
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-3102R
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详细内容
货号：BY-3102R
英文名称：Anti-Phospho-p56Dok2（Tyr299）
中文名称：磷酸化D酪氨酸激酶衰减蛋白2抗体
其他名称：名Docking protein 2 56kDa; Docking protein 2 antibody DOK 2; DOK R; Downstream of tyrosine kinase 2; p56（dok 2）; p56dok 2; p56DOK; p56dok2
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 45kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, pig, dog, hrs
产品介绍：Docking proteins interact with receptor tyrosine kinases ａnd mediate particular biological responses using signal transduction. DOK2 acts as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. By this mechanism it acts to negatively regulate signal transduction ａnd cell proliferation controlled by cytokines in a feedback loop. DOK2 is highly expressed in cells ａnd tissues of hematopoietic origin as well as in lung. Expression of bcr/abl induces additional tyrosine phosphorylation of the DOK1 ａnd DOK2 proteins ａnd their association with Ras-GAP. Thus, it is suspected that DOK association regulates GAP activity toward Ras ａnd that the DOK proteins serve as mediators of bcr-abl signaling. The role of DOK proteins in bcr-abl regulation may also be implicated in chronic myelogenous leukemia （CML）, which is characterized by a Philadelphia chromosome translocation t（9;22）. Such a mutation would result in a p210-bcr/abl chimeric protein-tyrosine kinase which has been found in many CML cases.Subunit : Interacts with phosphorylated RASGAP ａnd EGFR. Interacts with RET ａnd NCK. Interacts （via PH domain） with TEK/TIE2 （tyrosine phosphorylated）.Tissue Specificity : Highly expressed in spleen ａnd lung.Similarity : Belongs to the DOK family. Type A subfamily.Contains 1 IRS-type PTB domain.Contains 1 PH domain.
