产品展示
DRD4多巴胺受体D4抗体
点击次数：213发布时间：2012/12/5 14:12:33
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-1746R
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详细内容
货号：BY-1746R
英文名称：Anti-DRD4
中文名称：多巴胺受体D4抗体
其他名称：名DRD4 receptor; dopamine D4 receptor; D4 dopamine receptor.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 41（mo/ rat）; 51（human）kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia ａnd Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, ａnd the personality trait of novelty seeking. This gene contains a polymorphic number （2-10 copies） of tandem 48 nt repeats; the sequence shown contains four repeats.DRD4 expression has been reported in various regions of the brain as well as in adrenal gland, artery, eye, heart, kidney, placenta, spinal cord, testis, ａnd vas deferens.Subunit : Forms homo- ａnd heterooligomers with DRD2. D4.7 allele exhibits higher affinity for homodimers compared to DRD2 heterodimers, while alleles D42. ａnd 4.4 have similar affinities for both. The interaction with DRD2 may modulate agonist-induced downstream signaling. Interacts with CLIC6 （By similarity） ａnd GPRASP1. May interact with ADORA2A. Interacts with KLHL12.Subcellular Location : Cell membrane; Multi-pass membrane protein.Similarity : Belongs to the G-protein coupled receptor 1 family.
