产品展示
DP-II桥粒斑蛋白2抗体
点击次数：229发布时间：2012/12/5 14:15:59
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-1749R
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详细内容
货号：BY-1749R
英文名称：Anti-DP-II
中文名称：桥粒斑蛋白2抗体
其他名称：名250/210 kDa paraneoplastic pemphigus antigen; Desmoplakin （DPI DPII）; Desmoplakin; Desmoplakin I; Desmoplakin II; DP; DP I; DP II; DPI; DPII; DSP; PPKS 2; PPKS2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 250/210kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：Desmosomes are intercellular junctions that form tight links between adjacent cells. Desmoplakin is an obligate component of functional desmosomes that attaches intermediate filaments to desmosomal plaques. It is involved in the organization of desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains. The N-terminus of desmoplakin is essential for localisation to the desmosome ａnd interaction with plakophilin 1 ａnd plakoglobin. The C-terminus of desmoplakin binds to intermediate filaments. The central region of desmoplakin comprises a coiled-coil rod domain that mediates homodimerisation. There are two isoforms of desmoplakin - desmoplakin I, which is an obligate component of all desmosomes, ａnd desmoplakin II, which is predominantly expressed in tissues ａnd cells of stratified origin. Mutations in the gene encoding desmoplakin result in a number of cardiomyopathies ａnd keratodermas as well as the autoimmune disease paraneoplastic pemphigus.
