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phospho-Dnmt1(Tyr969)磷酸化DNA甲基转移酶1抗体
点击次数：208发布时间：2012/12/5 14:26:25
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-5297R
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详细内容
货号：BY-5297R
英文名称：Anti-phospho-Dnmt1（Tyr969）
中文名称：磷酸化DNA甲基转移酶1抗体
其他名称：名DNMT1; DNA （cytosine-5-）-methyltransferase 1; DNA methyltransferase HsaI; DNA MTase HsaI; MCMT; M.HsaI; CXXC-type zinc finger protein 9; Dnmt1; FLJ16293; AIM; DNMT; CXXC9; M.HsaI; DNA; MCMT; MGC104992; EC 2.1.1.37; DNA methyltransferase 1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 186kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, dog, pig, chk
产品介绍：The DNA methyltransferase 1 in various tumor cells the expression measure very high, but then low expression in normally become person＇s cell, so the high expression of the gene of dnmt1 ａnd the occurrence of the tumors contain close relation. A cells period, propagate ａnd the Apoptosis have certain of of influence.Subunit : Binds to CSNK1D （By similarity）. Homodimer. Interacts with HDAC1 ａnd with PCNA. Forms a complex with DMAP1 ａnd HDAC2, with direct interaction. Forms also a stable complex with E2F1, BB1 ａnd HDAC1. Binds MBD2 ａnd MBD3. Component of complexes containing SUV39H1. Interacts with DNMT3A ａnd DNMT3B. Interacts with the PRC2/EED-EZH2 complex. Interacts with UBC9 ａnd BAZ2A/TIP5.Subcellular Location : Nucleus.Tissue Specificity : Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, ａnd expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, ａnd skeletal muscle. Isoform 2 is less expressed than isoform 1.Similarity : Belongs to the C5-methyltransferase family.Contains 2 BAH domains.Contains 1 CXXC-type zinc finger.DNA甲基转移酶-1在多种肿瘤细胞中表达量相当高，而在正常成人细胞中则低表达，因此dnmt1基因的高表达与肿瘤的发生有密切的关系。 dnmt-1 对细胞周期、增殖及凋亡有一定的的影响。细胞核表达。 （isoform CRA_a）为抑制细胞增殖、促进细胞凋亡，为肿瘤的基因治疗提供依据。
