产品展示
DLL4/Delta 4Notch信号通路Delta样配体4抗体
点击次数：224发布时间：2012/12/5 14:28:11
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-6044R
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详细内容
货号：BY-6044R
英文名称：Anti-DLL4/Delta 4
中文名称：Notch信号通路Delta样配体4抗体
其他名称：名Delta 4; delta 4 precursor; Delta-4: Delta ligand 4; delta ligand 4 precursor; Delta like 4; Delta like 4 homolog; Delta like 4 protein; Delta like protein 4; Delta-like 4 （Drosophila）; Delta-like protein 4; Delta4; DLL 4; DLL4; DLL4_HUMAN antibody Drosophila Delta homolog 4; hdelta2; Homeobox protein DLL-4; MGC126344; Notch ligand delta 2; Notch ligand DLL4; notch ligand DLL4 precursor; XDLL-4.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 75kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, hrs, dog, cow
产品介绍：The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged-2 ａnd Delta. While blocking the differentiation of progenitor cells into the B-cell lineage, Delta promotes the emergence of a population of cells with T cell/NK-cell characteristics. The protein is a membrane protein expressed in heart, pancreas, brain ａnd muscle during gastrulation ａnd early organogenesis ａnd in adult heart ａnd lung. Delta-4 is a membrane protein that activates Notch-1 ａnd Notch-4. It is expressed in a wide range of adult ａnd fetal tissues, especially in vascular endothelium.Function : Plays a role in the Notch signaling pathway. Activates Notch-1 ａnd Notch-4.Subcellular Location : Membrane.Tissue Specificity : Expressed in vascular endothelium.Post-translational modifications : Ubiquitinated by MIB （MIB1 or MIB2）, leading to its endocytosis ａnd subsequent degradation.Similarity : Contains 1 DSL domain.Contains 8 EGF-like domains.
