产品展示
DRD1多巴胺受体D1抗体
点击次数：242发布时间：2012/12/5 14:29:04
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-1007R
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详细内容
货号：BY-1007R
英文名称：Anti-DRD1
中文名称：多巴胺受体D1抗体
其他名称：名D（1A） dopamine receptor; D1A dopamine receptor; Dopamine D1Receptors; D1DR; DADR; Dopamine Receptor D1; DR D1; DR D1A; DRD 1; DRD1 receptor; DRD1; DRD1A.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 50kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G protein coupled receptor stimulates adenylyl cyclase ａnd activates cyclic AMP dependent protein kinases. D1 receptors regulate neuronal growth ａnd development, mediate some behavioral responses, ａnd modulate dopamine receptor D2 mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. Dopamine receptor D1 has been reported mostly in various regions of the brain. ESTs have been isolated from normal olfactory epithelium ａnd cancerous genitourinary tract libraries.Subunit : Interacts with DNAJC14 via its C-terminus. Interacts with DRD1IP.Subcellular Location : Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.Tissue Specificity : Detected in caudate, nucleus accumbens ａnd in the olfactory tubercle.Similarity : Belongs to the G-protein coupled receptor 1 family.多巴胺受体D1在运动协调方面起重要作用，该受体的缺失对黑质多巴胺能神经元的影响程度虽没临床帕金森病（PD）严重，但仍可加速多巴胺能神经元发生退行性改变.该蛋白目前主要用于神经退行性改变的研究。
