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phospho-DVL2(Thr224)磷酸化蓬乱蛋白2抗体
点击次数：196发布时间：2012/12/5 14:31:02
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-9060R
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货号：BY-9060R
英文名称：Anti-phospho-DVL2（Thr224）
中文名称：磷酸化蓬乱蛋白2抗体
其他名称：名Dishevelled 2 （phospho T224）;Dishevelled 2 （homologous to Drosophila dsh）; Dishevelled dsh homolog 2; Dishevelled-2; Dishevelled2; DSH homolog 2; DVL 2; Dvl2; DVL2_HUMAN; Segment polarity protein dishevelled homolog DVL 2; Segment polarity protein dishevelled homolog DVL-2; Segment polarity protein dishevelled homolog DVL2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 78kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Mammalian homologs of the Drosophila dishevelled （Dsh） gene have been identified, including Dvl-1, Dvl-2 ａnd Dvl-3. The mammalian dishevelled proteins contain three homologous domains, two of which are unrelated to any other known protein. The third region is homologous to the discs-large homology domain of Drosophila discs-large-1, a tumor suppressor protein. Like their Drosophila counterpart, the dishevelled proteins are thought to be involved in embryogenesis. Overexpression of Dvl-1 has been shown to inhibit the phosphorylation of tau by GSK-3? This finding may prove to be important in Alzheimer抯 studies, which have shown that tau is hyperphosphorylated. In Drosophila, Dsh is a component of the frizzled signaling pathway. Both mammalian dishevelled ａnd frizzled proteins are components of the Wnt signalling pathway.Subcellular Location : Subcellular Location : Cell membrane. Cytoplasm > cytosol. Cytoplasmic vesicle. Localizes at the cell membrane upon interaction with frizzled family members ａnd promotes their internalization. Localizes to cytoplasmic puncta.
