产品展示
DR1 protein转录下调蛋白1抗体
点击次数：203发布时间：2012/12/5 14:32:26
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-9055R
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详细内容
货号：BY-9055R
英文名称：Anti-DR1 protein
中文名称：转录下调蛋白1抗体
其他名称：名Dr1 protein;NC2;Negative cofactor 2 beta;Down regulator of transcription 1;Down regulator of transcription 1 TBP binding;Down-regulator of transcription 1;DR 1;Dr1;NC 2;NC2 beta;NC2-beta;NC2B_HUMAN;Negative co factor 2;Negative cofactor 2;Negative cofactor 2-beta;Protein Dr1;TATA binding protein associated phosphoprotein;TATA-binding protein-associated phosphoprotein.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 20kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：DR1, also known as NC2∫ （negative cofactor 2 subunit ∫）, is a TFIID （TATA box-binding protein）-associated protein. DR1 localizes to the nucleus ａnd contains an N-terminal histone fold motif, a TFIID-binding domain ａnd an alanine ａnd glutamine rich region. Via its histone fold motif, DR1 forms a heterodimer with NC2å （DRAP1） to comprise the conserved eukaryotic complex, NC2 （negative cofactor 2）. The NC2 complex can both positively ａnd negatively regulate transcription by RNA Pol II. More specifically, NC2 acts as a repressor of TATA-dependent transcription ａnd acts as an activator for DPE-dependent transcription. NC2 represses RNA Pol II transcription by binding to TFIID ａnd inhibiting association of the transcription factors TFIIA ａnd TFIIB. NC2 activity is regulated by phosphorylation. Both subunits, NC2å ａnd DR1, are phosphorylated in vivo.Subcellular Location : Nucleus
