产品展示
DLL3Notch信号通路Delta样配体3抗体
点击次数：204发布时间：2012/12/5 14:34:43
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-7860R
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详细内容
货号：BY-7860R
英文名称：Anti-DLL3
中文名称：Notch信号通路Delta样配体3抗体
其他名称：名Delta Drosophila like 3; Delta like 3 Drosophila; Delta like 3 homolog Drosophila; Delta like 3 protein; Delta like protein 3 precursor; Delta3; Drosophila Delta homolog 3; SCDO1; Spondylocostal dysostosis autosomal recessive.DLL3_HUMAN
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 65kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, hrs, dog, cow, Rb
产品介绍：Delta-like 3 （DLL3） is a transmembrane Delta-like protein that inhibits primary neurogenesis. It may be required to divert neurons along a specific differentiation pathway ａnd plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 is one of five DSL proteins that bind to the Notch receptor ａnd activates Notch signaling.Function : Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.Subunit : Can bind ａnd activate Notch-1 or another Notch receptor （Probable）.Subcellular Location : Membrane; Single-pass type I membrane protein （Probable）.Tissue Specificity : Predominantly expressed in the neuroectoderm ａnd paraxial mesoderm during embryogenesis.Post-translational modifications : Ubiquitinated by MIB （MIB1 or MIB2）, leading to its endocytosis ａnd subsequent degradation.DISEASE : Note=A truncating mutation in Dll3 is the cause of the pudgy （pu） phenotype. Pudgy mice exhibit patterning defects at the earliest stages of somitogenesis. Adult pudgy mice present severe vertebral ａnd rib deformities.Similarity : Contains 1 DSL domain.Contains 6 EGF-like domains.
