产品展示
Entactin/Nidogen巢蛋白1抗体
点击次数：640发布时间：2012/12/5 14:35:18
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-6911R
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详细内容
货号：BY-6911R
英文名称：Anti-Entactin/Nidogen
中文名称：巢蛋白1抗体
其他名称：名Ent; Entactin 1; Entactin; NID 1; NID; NID-1; Nid1; NID1_HUMAN; Nidogen （enactin）; Nidogen 1; Nidogen; Nidogen-1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 134kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, Rb
产品介绍：Basement membranes are the earliest extracellular matrices produced during embryogenesis. They are synthesized ａnd incorporated into the supramolecular architecture of several components, including laminins, Collagen IV, Nidogen ａnd proteoglycans. Nidogen/Entactin, a sulfated glycoprotein, acts as a link between the extracellular matrix molecules Laminin 1 ａnd Collagen Type IV, ａnd thereby participates in the assembly of basement membranes. Nidogen is a highly conserved member of the Nidogen family, which also includes Nidogen-2. Nidogen-2 has a high level of N- ａnd O-glycosylation, ａnd it interacts with Collagens Type I ａnd IV ａnd Perlecan at a comparable level to Nidogen. Nidogen is synthesized ａnd secreted in primary ａnd established mesenchymal peritubular cells ａnd myoepithelial cells, ａnd it affects adhesion of peritubular cells in an autocrine manner. Nidogen is expressed during embryonic ａnd fetal development exclusively in fully developed basement membranes of the ectoderm ａnd is not expressed in the developing endodermal basement membrane or in membranes disrupted during mesoderm formation. Nidogen also cooperates with Laminin 1 to regulate b-casein expression.Subunit : Interacts with FBLN1 ａnd LGALS3BP. Interacts with PLXDC1.Subcellular Location : Secreted, extracellular space, extracellular matrix, basement membrane.Similarity : Contains 6 EGF-like domains.Contains 1 NIDO domain.Contains 1 nidogen G2 beta-barrel domain.Contains 1 thyroglobulin type-1 domain.
