产品展示
EGR2早期生长反应蛋白2抗体
点击次数：233发布时间：2012/12/5 14:36:10
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-8368R
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详细内容
货号：BY-8368R
英文名称：Anti-EGR2
中文名称：早期生长反应蛋白2抗体
其他名称：名CMT1D;CMT4E;DKFZp686J1957;Early growth response 2;Early growth response protein 2;EGR-2;egr2;EGR2_HUMAN;FLJ14547;KROX 20 Drosophila homolog;Krox 20 homolog Drosophila;KROX20;Krox20 protein;Zinc finger protein Krox-20;AT591.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 42kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Egr proteins function in transcription regulatory activities surrounding cellular growth, differentiation ａnd function. The deduced amino acid sequences of human Egr-2 ａnd mouse Egr-1 are 92% identical in the zinc finger region but show no homology elsewhere. Egr-2 is a sequence-specific DNA-binding transcription factor that binds two specific DNA sites located in the promoter region of HoxA4 ａnd localizes to the nucleus. Defects in the Egr-2 protein are a cause of congenital hypomyelination neuropathy （CHN）. CHN is characterized clinically by early onset of hypotonia, areflexia, distal muscle weakness ａnd very slow nerve conduction velocities. Mutations in the gene that encodes Egr-2 （EGR2） also cause Dejerine-Sottas syndrome （DSS）, which is also known as Dejerine-Sottas neuropathy （DSN） or hereditary motor ａnd sensory neuropathy III （HMSN3）. DSS patients exhibit severe early onset motor ａnd sensory neuropathy with very slow nerve conduction velocities ａnd elevated cerebrospinal fluid protein concentrations.Subcellular Location : Nucleus.
