本公司经销ECS1/Flotillin 2，表皮细胞表面抗原1抗体，克隆类型为polyclonal，宿主来源是Rabbit，ECS1/Flotillin 2表皮细胞表面抗原1抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-11254R
英文名称：Anti-ECS1/Flotillin 2
中文名称：表皮细胞表面抗原1抗体
其他名称：名ECS-1;ECS1;Epidermal surface antigen 1;Epidermal surface antigen;ESA;ESA1;Flot2;FLOT2_HUMAN;Flotillin-2;M17S1 antibodyMembrane component chromosome 17 surface marker 1;Membrane component chromosome 17 surface marker 1 homolog;Membrane component, chromosome 17, surface marker 1;REG-1;Reggie-1;Reggie-2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 47kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Lipid rafts are sphingolipid- ａnd cholesterol-rich membrane microdomains that are insoluble in nonionic detergents. Lipid rafts are important for numerous cellular processes, including signal transduction, membrane trafficking ａnd molecular sorting. Flotillins are lipid raft components in neurons ａnd caveloae-associated proteins in A498 kidney cells. Flotillin-2, also designated epidermal surface antigen, is conserved in all mammalian species. Flotillin-1 ａnd -2 have complementary tissue distributions ａnd their expression levels are independently regulated. At the cellular level, Flotillin-2 is ubiquitously expressed, whereas Flotillin-1 is expressed in A498 kidney cells, muscle cell lines ａnd fibroblasts. Stable transfection of a Flotillin-2 fusion protein in COS cells induces filopodia formation ａnd changes epithelial cells to a neuronal appearance. Flotillins form a ternary complex with CAP ａnd Cbl, directing the localization of the CAP-Cbl complex to a lipid raft subdomain of the plasma membrane. Association of ER-X with Flotillin localizes ER-X within plasma membrane caveloae ａnd mediates rapid oestrogen activation of the MAP kinase cascade. The expression of the flotillins is also correlated to the progression of Alzhemier pathology.Function : May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion ａnd epidermal structure ａnd function.Subcellular Location : Cell membrane. Membrane > caveola. Endosome. Membrane-associated protein of caveolae.Tissue Specificity : In skin, expressed in epidermis ａnd epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma ａnd carcinoma cell lines, fibroblasts ａnd foreskin melanocytes.Similarity : Belongs to the band 7/mec-2 family. Flotillin subfamily.