产品展示
E2F3转录因子E2F-3抗体
点击次数：2383发布时间：2012/12/5 14:40:55
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-1722R
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详细内容
货号：BY-1722R
英文名称：Anti-E2F3
中文名称：转录因子E2F-3抗体
其他名称：名DKFZp686C18211; E2F 3; E2F transcription factor 3; KIAA0075; MGC104598; Transcription factor E2F 3; Transcription factor E2F3.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 51kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, dog, cow, hrs, Rb
产品介绍：The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle ａnd action of tumor suppressor proteins ａnd is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins （DP）, a transactivation domain enriched in acidic amino acids, ａnd a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein ａnd another 2 members, E2F1 ａnd E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. [provided by RefSeq].Function : Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5＇-TTTC[CG]CGC-3＇ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-3 binds specifically to RB1 protein, in a cell-cycle dependent manner.Subcellular Location : Nucleus.Similarity : Belongs to the E2F/DP family. 转录调节因子（Transcriptin Regulators） E2F3转录因子具有调控细胞增殖、分化和凋亡相关基因转录的重要作用.
