产品展示
E2F5转录因子E2F-5抗体
点击次数：239发布时间：2012/12/5 14:41:10
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-1734R
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详细内容
货号：BY-1734R
英文名称：Anti-E2F5
中文名称：转录因子E2F-5抗体
其他名称：名E2F-5; transcription factor E2F5; E2F 5; E2F transcription factor 5; E2F transcription factor 5 p130 binding; p130 binding.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 38kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, hrs, pig, cow, dog, chk
产品介绍：The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle ａnd action of tumor suppressor proteins ａnd is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins （DP）, a transactivation domain enriched in acidic amino acids, ａnd a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated ａnd is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein ａnd E2F4 interact with tumor suppressor proteins p130 ａnd p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms.E2F5转录因子具有调控细胞增殖、分化和凋亡相关基因转录的重要作用.产品图片Antigen: bs-1734P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.
