产品展示
EpCAM/CD326上皮细胞粘附分子抗体
点击次数:289发布时间:2012/12/5 14:52:26
更新日期:2024/9/5 14:43:01
所 在 地:中国大陆
产品型号:BY-1513R
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详细内容
货号:BY-1513R
英文名称:Anti-EpCAM/CD326
中文名称:上皮细胞粘附分子抗体
其他名称:名 Adenocarcinoma associated antigen; CD326; CD326 antigen; Cell surface glycoprotein Trop 1; CO17 1A; EGP; EGP40; Ep CAM; Epithelial cell surface antigen; Epithelial cellular adhesion molecule; Epithelial glycoprotein; GA733 2; hEGP 2; KS 1/4 antigen; KSA; Lymphocyte antigen 74; M1S2; M4S1; Major gastrointestinal tumor associated protein GA733 2; MIC18; MK 1; TACD1; TACSTD1; TROP1; Tumor associated calcium signal transducer 1.
抗体来源:Rabbit
克隆类型:polyclonal
蛋白分子量:predicted molecular weight: 35kDa
纯化方法:affinity purified by Protein A
交叉反应:hu, mo, rat
产品介绍:Epithelial Cell Adhesion Molecule (EpCAM) is a 40 kDa cell surface antigen. This antigen has been identified independently by a number of groups, and has been known by a variety of names. Several monoclonal antibodies have been raised against EpCAM, many of which have been described as tumour specific molecules on carcinomas. EpCAM is a Type 1 transmembrane glycoprotein. It is expressed on the basolateral membrane of cells by the majority of epithelial tissues, with the exception of adult squamous epithelium and some specific epithelial cell types including hepatocytes and gastric epithelial cells. EpCAM expression has been reported to be a possible marker of early malignancy, with expression being increased in tumour cells, and de novo expression being seen in dysplastic squamous epithelium.Subunit : Monomer. Interacts with phosphorylated CLDN7.Subcellular Location : Lateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction.Tissue Specificity : Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.Similarity : Belongs to the EPCAM family.Contains 1 thyroglobulin type-1 domain.