本公司经销Phospho-EGFR （Tyr1138），磷酸化表皮生长因子受体抗体，克隆类型为polyclonal，宿主来源是Rabbit，Phospho-EGFR （Tyr1138）磷酸化表皮生长因子受体抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-3109R
英文名称：Anti-Phospho-EGFR （Tyr1138）
中文名称：磷酸化表皮生长因子受体抗体
其他名称：名Epidermal growth factor receptor; p170EGFR; ERBB1; HER1; Avian erythroblastic leukemia viral （verbb） oncogene homolog; EGF R; EGFR; erbb 1; Erbb; Erbb1; mENA; Oncogene ERBB; Receptor tyrosine protein kinase ErbB1; Urogastrone; wa2; Wa5.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 130kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, Rb
产品介绍：Epidermal growth factor Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 ａnd vaccinia virus growth factor. Is involved in the control of cell growth ａnd differentiation. Expressed in placenta. Isoform 2 is also expressed in ovarian cancers. Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, ａnd cell proliferation. Belongs to the Tyr protein kinase family. EGF receptor subfamily.Subunit : Binding of the ligand triggers homo- and/or heterodimerization of the receptor triggering its autophosphorylation. Heterodimer with ERBB2.Subcellular Location : Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome. Endosome membrane. Isoform 2: Secreted.Tissue Specificity : Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.Contains 1 protein kinase domain.细胞膜受体（Membrane Receptors） EGFR-血管内皮生长因子受体EGFR是一类分子量为170kDa的糖蛋白，在生长的细胞包括中瘤细胞中跨越细胞质膜，表现有蛋白激酶活性。 EGFR是一种细胞膜受体激酶，对血管内皮生长因子有高度的亲和性，主要功能是参与血管内皮细胞生长和血管生成的调控,主要用于各种恶性肿瘤的研究.与其配体表皮生长因子或尿抑胃素结合后则被激活，从而启动DNA及蛋白质的合成。再不进行有丝分裂的细胞中并不存在，但在胃中例外。 大量研究报道显示，EGFR高表达的肿瘤生存降低、转移风险增高、预后不良。在很多肿瘤中都存在着EGFR表达或过度表达。这些疾病包括：结直肠癌（CRC）、头颈部鳞状细胞癌（SCCHN）、乳腺癌、卵巢癌、宫颈癌、食道癌、胰腺癌、膀胱癌、前列腺癌和非小细胞肺癌等。研究表明，EGFR表达的肿瘤恶性程度增高、侵袭性强，这类肿瘤患者往往生存降低、转移风险增高、预后不良。