本公司经销Exportin 1/CRM1，染色体区域稳定蛋白/核输出蛋白1/染色体区域稳定必需蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，Exportin 1/CRM1染色体区域稳定蛋白/核输出蛋白1/染色体区域稳定必需蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-2953R
英文名称：Anti-Exportin 1/CRM1
中文名称：染色体区域稳定蛋白/核输出蛋白1/染色体区域稳定必需蛋白抗体
其他名称：名Chromosome region maintenance 1 protein homolog; CRM 1; CRM1 homolog; DKFZp686B1823; Exp 1; Exp-1;Exp1; Exportin 1; Exportin1; Exportin-1; XPO 1; XPO1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 118kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig
产品介绍：CRM1 （chromosome region maintenance 1 protein homolog） mediates the nuclear export of cellular proteins （cargoes） bearing a leucine-rich nuclear export signal （NES） ａnd of RNAs. In the nucleus, in association with RANBP3, CRM1 binds cooperatively to the NES on its target protein ａnd to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex （NPC） is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex ａnd hydrolysis of Ran-GTP to Ran-GDP （induced by RANBP1 ａnd RANGAP1, respectively） cause release of the cargo from the export receptor. The direction of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- ａnd GDP-bound forms of Ran between the cytoplasm ａnd nucleus. CRM1 also mediates the nuclear export of the Rev protein of HIV-1 ａnd Rex protein of HTLV-1. It is involved in Rex dimerization, U3 snoRNA transport from Cajal bodies to nucleoli. CRM1 is also involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, ａnd MAPKAP kinase 2. CRM1 is also involved in the regulation NFAT ａnd AP-1.Subunit : Found in a U snRNA export complex with RNUXA/PHAX, NCBP1, NCBP2, RAN, XPO1 ａnd m7G-capped RNA （By similarity）. Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN ａnd XPO1. Found in a trimeric export complex with SNUPN, RAN ａnd XPO1. Found in a nuclear export complex with RANBP3 ａnd RAN. Found in a 60S ribosomal subunit export complex with NMD3, RAN, XPO1. Interacts with DDX3X, NMD3, NUPL2, NUP88, NUP214, RANBP3 ａnd TERT. Also found in complex with several viral proteins involved in RNAs＇ nuclear export like HIV-1 Rev ａnd HTLV-1 Rex. Interacts presumably with influenza A nucleoprotein. Interacts with Epstein-Barr virus BMLF1. Interacts with NEMF （via its N-terminus）. Interacts with the monomeric form of BIRC5/survivin deacetylated at ＇Lys-129＇.Subcellular Location : Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Note=Located in the nucleoplasm, Cajal bodies ａnd nucleoli. Shuttles between the nucleus/nucleolus ａnd the cytoplasm.Tissue Specificity : Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon ａnd peripheral blood leukocytes. Not expressed in the kidney.Similarity : Belongs to the exportin family.Contains 10 HEAT repeats.Contains 1 importin N-terminal domain.