产品展示
EN2/Engrailed 2同源盒蛋白转录因子EN2抗体
点击次数：299发布时间：2012/12/5 15:29:58
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-11552R
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详细内容
货号：BY-11552R
英文名称：Anti-EN2/Engrailed 2
中文名称：同源盒蛋白转录因子EN2抗体
其他名称：名AUTS 1;AUTS1;EN 2;Engrailed 2;Engrailed homeo box 2;Engrailed homeobox 2;Engrailed homolog 2;Engrailed2;Homeobox protein engrailed 2;Homeobox protein engrailed2;Hu En 2;HuEn2;MabEn.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 34kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, chi
产品介绍：The engrailed-2 gene, EN2, a murine homolog of the Drosophila homeobox gene engrailed （EN）, is required for midbrain ａnd cerebellum development ａnd dorsal/ventral patterning of the limbs as well as apical ectodermal ridge formation. In Drosophila, the EN gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Human EN-1 ａnd EN-2 are homeodomain-containing proteins ａnd have been implicated in the control of pattern formation during development of the central nervous system. Different mutations in the mouse homologs, EN-1 ａnd EN-2, produce different developmental defects that frequently are lethal. EN-1 is highly expressed by essentially all dopaminergic neurons in the substantia nigra ａnd ventral tegmentum. EN-1 ａnd EN-2 regulate expression of a-synuclein, a gene that is genetically linked to Parkinson’s disease. During early brain development mouse EN-2 is expressed in a broad band across most of the mid-hindbrain region. EN-2 is also expressed in mouse myoblasts ａnd has been assiciated with cerebellar hypoplasia.Function : EN1 ａnd EN2 encode homeodomain containing proteins ａnd have been implicated in the control of pattern formation during development of the central nervous system. EN2 may play a role in susceptibility to autism spectrum disorders.Subcellular Location : Nuclear
