本公司经销E-cadherin/CD324，上皮钙粘附分子抗体，克隆类型为polyclonal，宿主来源是Rabbit，E-cadherin/CD324上皮钙粘附分子抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1519R
英文名称：Anti-E-cadherin/CD324
中文名称：上皮钙粘附分子抗体
其他名称：名Arc 1; Cadherin 1; E cadherin; cadherin 1 type 1 E-cadherin; Cadherin1; CAM 120/80; CD 234; CD324; CD324 antigen; CDH1; CDHE; ECAD; Epithelial cadherin; epithelial calcium dependant adhesion protein; LCAM; Liver cell adhesion molecule; UVO; Uvomorulin.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 20/80kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, cow, pig, hrs, chk
产品介绍：Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility ａnd proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 ａnd C83 production.Function : Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility ａnd proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 ａnd C83 production.Subunit : Homodimer.Subcellular Location : Cell junction. Cell membrane; Single-pass type I membrane protein.Tissue Specificity : Non-neural epithelial tissues.Post-translational modifications : During apoptosis or with calcium influx, cleaved by a membrane-bound metalloproteinase （ADAM10）, PS1/gamma-secretase ａnd caspase-3 to produce fragments of about 38 kDa （E-CAD/CTF1）, 33 kDa （E-CAD/CTF2） ａnd 29 kDa （E-CAD/CTF3）, respectively. Processing by the metalloproteinase, induced by calcium influx, causes disruption of cell-cell adhesion ａnd the subsequent release of beta-catenin into the cytoplasm. The residual membrane-tethered cleavage product is rapidly degraded via an intracellular proteolytic pathway. Cleavage by caspase-3 releases the cytoplasmic tail resulting in disintegration of the actin microfilament system. The gamma-secretase-mediated cleavage promotes disaaaembly of adherens junctions.DISEASE : Defects in CDH1 are involved in dysfunction of the cell-cell adhesion system, triggering cancer invasion （gastric, breast, ovary, endometrium ａnd thyroid） ａnd metastasis.Defects in CDH1 are a cause of gastric cancer [MIM:137215]; also known as hereditary familial diffuse gastric cancer （HDGC）.Defects in CDH1 are a cause of susceptibility to endometrial cancer [MIM:608089].Defects in CDH1 are associated with ovarian cancer [MIM:167000]. Ovarian cancer is the leading cause of death from gynecologic malignancy. It is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity ａnd the rare incidence of visceral metastases. These typical features relate to the biology of the disease, which is a principal determinant of outcome.Similarity : Contains 5 cadherin domains.细胞粘附蛋白（Call Adhesion Protein） E-chaherin是研究较多的同质粘附分子。E-cadherin的表达与恶性肿瘤的分化程度、侵袭力、转移负相关与预后正相关，E-cadherin的低表达和不稳定表达可促进转移的发生。近年来已成为肿瘤细胞侵袭和转移研究的热点。