本公司经销ENPP2，核苷酸焦磷酸酶2抗体，克隆类型为polyclonal，宿主来源是Rabbit，ENPP2核苷酸焦磷酸酶2抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-6279R
英文名称：Anti-ENPP2
中文名称：核苷酸焦磷酸酶2抗体
其他名称：名ATX; ATX X; Autotaxin; Autotaxin t; E NPP 2; E-NPP 2; Ectonucleotide pyrophosphatase/phosphodiesterase 2; Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; Enpp2; ENPP2_HUMAN; Extracellular lysophospholipase D; LysoPLD; NPP2; PD IALPHA; PDNP2; Phosphodiesterase I alpha; Phosphodiesterase I/nucleotide pyrophosphatase 2; Plasma lysophospholipase D.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 95kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, hrs, cow, dog, chk, Rb
产品介绍：Hydrolyzes lysophospholipids to produce lysophosphatidic acid （LPA） in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, ａnd barely ATP. Involved in several motility-related processes such as angiogenesis ａnd neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells ａnd microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation ａnd adipose tissue development. Tumor cell motility-stimulating factor.Function : Hydrolyzes lysophospholipids to produce lysophosphatidic acid （LPA） in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, ａnd barely ATP. Involved in several motility-related processes such as angiogenesis ａnd neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells ａnd microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation ａnd adipose tissue development. Tumor cell motility-stimulating factor.Subcellular Location : Secreted. Note=Secreted by most body fluids including serum ａnd CSF. Also by adipocytes ａnd numerous cancer cells.Tissue Specificity : Predominantly expressed in brain, placenta, ovary, ａnd small intestine. Expressed in a number of carcinomas such as hepatocellular ａnd prostate carcinoma, neuroblastoma ａnd non-small-cell lung cancer. Expressed in body fluids such as plasma, cerebral spinal fluid （CSF）, saliva, follicular ａnd amniotic fluids. Not detected in leukocytes. Isoform 1 is more highly Eexpressed in peripheral tissues than in the central nervous system （CNS）. Adipocytes only express isoform 1. Isoform 3 is more highly expressed in the brain than in peripheral tissues.Post-translational modifications : N-glycosylation, but not furin-cleavage, plays a critical role on secretion ａnd on lysoPLD activity （By similarity）.It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.Similarity : Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. Contains 2 SMB （somatomedin-B） domains.