本公司经销eIF6/ITGB4BP，β4整合素结合蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，eIF6/ITGB4BPβ4整合素结合蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-3844R
英文名称：Anti-eIF6/ITGB4BP
中文名称：β4整合素结合蛋白抗体
其他名称：名b（2）gcn; B（2）GCN homolog; B4 integrin interactor; Binding protein of beta-4 integrin; CAB; eIF-6; EIF3A; EIF6; Eukaryotic translation initiation factor 3A; Eukaryotic translation initiation factor 6; IF6_HUMAN; ITGB4BP; OK/SW-cl.27; p27 beta 4 integrin binding protein; p27（BBP）; p27BBP; RP4-614O4.1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 27kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, shp, cow, pig, hrs, Rb
产品介绍：Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit （ITGB4）, a protein containing two fibronectin type III domains. The protein encoded by Intergrin beta 4 binding protein binds to the fibronectin type III domains of ITGB4 ａnd may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble ａnd found both in the nucleus ａnd in the cytoplasm, can function as a translation initiation factor ａnd prevent the association of the 40S ａnd 60S ribosomal subunits. Multiple transcript variants encoding several different isoforms have been found for this gene.Function : Binds to the 60S ribosomal subunit ａnd prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus ａnd is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits ａnd nuclear relocalization is promoted by a RACK1 （GNB2L1）-dependent protein kinase C activity.Subunit : Belongs to the eIF-6 family.Subcellular Location : Cytoplasm. Nucleus. nucleolus. Shuttles between cytoplasm ａnd nucleus/nucleolus.Tissue Specificity : Expressed at very high levels in colon carcinoma with lower levels in normal colon ａnd ileum ａnd lowest levels in kidney ａnd muscle （at protein level）.Post-translational modifications : Phosphorylation at Ser-174 ａnd Ser-175 by CSNK1D/CK1 promotes nuclear export.Similarity : Belongs to the eIF-6 family.