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Phospho-ELk1 (Ser389)磷酸化细胞转录因子ELK1抗体
点击次数：256发布时间：2012/12/5 16:00:52
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-5335R
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详细内容
货号：BY-5335R
英文名称：Anti-Phospho-ELk1 （Ser389）
中文名称：磷酸化细胞转录因子ELK1抗体
其他名称：名Elk-1（Phospho-Ser389）; ELK 1; ELK1 member of ETS oncogene family; ELK1 protein; ELK2 member of ETS oncogene family; ETS domain containing protein Elk 1; ETS domain containing protein Elk1; ETS domain protein Elk1;Oncogene Elk1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 45kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：The transcription factor Elk1 is a component of the ternary complex that binds the serum response element （SRE） ａnd mediates gene activity in response to serum ａnd growth factors. Elk1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C terminus. Phosphorylation at these sites, particularly Ser383, is critical for transcriptional activation by Elk1. Elk1 appears to be a direct target of activated MAP kinase. Biochemical studies indicate that Elk1 is a good substrate for MAP kinase, the kinetics of Elk1 phosphorylation ａnd activation correlate with MAP kinase activity, ａnd interfering mutants of MAP kinase block Elk1 activation in vivo. More recent studies have shown that Elk1 （Ser383） is also a target of the Stress Activated Kinase SAPK/JNK. Phosphorylation of Elk1 has also been implicated in synaptic plasticity in the adult hippocampus.细胞转录因子ELK1是ETS致癌基因家族的一种。
