本公司经销EphA4，酪氨酸蛋白激酶A4抗体，克隆类型为polyclonal，宿主来源是Rabbit，EphA4酪氨酸蛋白激酶A4抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1764R
英文名称：Anti-EphA4
中文名称：酪氨酸蛋白激酶A4抗体
其他名称：名Ephrin receptor ligand binding domain; TYRO1; Cek 8 ; EphA4; Ephrin receptor Eph A4; Ephrin type A receptor 4; HEK 8; Receptor protein tyrosine kinase HEK 8; Sek 1; SEK; TYRO 1 protein tyrosine kinase; Tyrosine protein kinase receptor SEK.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 108kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb, pig, hrs, dog, chk
产品介绍：Eph receptor A4 is a receptor for members of the ephrin-A family. It binds to ephrin-A1, -A4 ａnd -A5 but binds more poorly to ephrin-A2 ａnd -A3. Eph receptor A4 may play a role in a signal transduction process involved in hindbrain pattern formation. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement ａnd cell movement, apoptosis, ａnd differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine （PTK） or serine/threonine （STK） kinase catalytic domains. The tyrosine kinase （TK） group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility ａnd death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK （e.g. EGFR, EPH, FGFR, PDGFR, TRK, ａnd VEGFR families）, ａnd 32 of cytosolic TK （e.g. ABL, FAK, JAK, ａnd SRC families）.Subunit : Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer ａnd a receptor dimer. Oligomerization is probably required to induce biological responses. Interacts （phosphorylated at position Tyr-602） with FYN. Interacts with CDK5, CDK5R1 ａnd NGEF; upon activation by EFNA1 induces NGEF phosphorylation by the kinase CDK5. Interacts with CHN1; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation （By similarity）. Interacts （via PDZ motif） with SIPA1L1 （via PDZ domain）; controls neuronal morphology through regulation of the RAP1 （RAP1A or RAP1B） ａnd RAP2 （RAP2A, RAP2B or RAP2C） GTPases.Subcellular Location : Cell membrane; Single-pass type I membrane protein （By similarity）. Cell projection, axon （By similarity）. Cell projection, dendrite （By similarity）. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density （By similarity）. Early endosome （By similarity）. Note=Clustered upon activation ａnd targeted to early endosome （By similarity）.Tissue Specificity : Ubiquitous.Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Contains 1 Eph LBD （Eph ligand-binding） domain. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain.Contains 1 SAM （sterile alpha motif） domain.