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Phospho-Estrogen Receptor alpha (Ser118)磷酸化雌激素受体α抗体
点击次数：215发布时间：2012/12/5 16:10:40
更新日期：2024/9/5 14:43:01
所 在 地：中国大陆
产品型号：BY-3130R
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货号：BY-3130R
英文名称：Anti-Phospho-Estrogen Receptor alpha （Ser118）
中文名称：磷酸化雌激素受体α抗体
其他名称：名Estrogen Receptor α（Estrogen-Ser118）; Phospho-Estrogen Receptor α（Ser118）; estrogen receptor alpha; DKFZp686N23123; ER alpha; ER; Era; ESR 1; ESR; ESR1; ESRA; Estradiol receptor; Estrogen receptor 1; Major ORF; NR3A1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 67kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, Rb
产品介绍：Estrogen ａnd progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements（EREs） alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, ａnd the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha ａnd ER beta. ER alpha ａnd ER beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor （hPR-A ａnd hPR-B）, which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors.Subunit : Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with FOXC2, MAP1S, SLC30A9, UBE1C ａnd NCOA3 coactivator （By similarity）.Subcellular Location : Isoform 1, Isoform 3: Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.Similarity : Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain.
