本公司经销EphB6，酪氨酸蛋白激酶受体B6抗体，克隆类型为polyclonal，宿主来源是Rabbit，EphB6酪氨酸蛋白激酶受体B6抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-2571R
英文名称：Anti-EphB6
中文名称：酪氨酸蛋白激酶受体B6抗体
其他名称：名EPH receptor B6; EphB6; EPHRIN RECEPTOR EphB6; Ephrin type B receptor 6 precursor; HEP; MGC129910; MGC129911; Tyrosine protein kinase defective receptor EPH 6.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 111kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, hrs, dog
产品介绍：Ephrin receptors ａnd their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures ａnd sequence relationships, ephrins are divided into the ephrin-A （EFNA） class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, ａnd the ephrin-B （EFNB） class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences ａnd their affinities for binding ephrin-A ａnd ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase （RTK） family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases ａnd binds to ephrin-B ligands. [provided by RefSeq, Jul 2008].Subunit : Interacts with CBL ａnd EPHB1. Interacts with FYN; this interaction takes place in a ligand-independent manner.Subcellular Location : Membrane; Single-pass type I membrane protein. Isoform 3: Secreted.Tissue Specificity : Expressed in brain. Expressed in non invasive breast carcinoma cell lines （at protein level）. Strong expression in brain ａnd pancreas, ａnd weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle ａnd kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas ａnd astrocytomas. Isoform 3 is not detected in normal tissues.Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.Contains 1 Eph LBD （Eph ligand-binding） domain.Contains 2 fibronectin type-III domains.生长因子和激素（ Growth Factor ａnd Hormones） 有学者认为：EPHB6受体型酪氨酸蛋白激酶与多种肿瘤的发生和转移负相关，EPHB6作为一种重要的生物学标记，还有许多未知的蛋白功能。