本公司经销Emerin，Emerin蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，EmerinEmerin蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-6660R
英文名称：Anti-Emerin
中文名称：Emerin蛋白抗体
其他名称：名EDMD; EMD; EMD_HUMAN; Emerin; Emery Dreifuss muscular dystrophy; STA.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 28kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Stabilizes ａnd promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding ａnd stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD ａnd BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF ａnd viral integrase. The association of viral DNA with chromatin requires the presence of BAF ａnd EMD. Required for proper localization of non-farnesylated prelamin-A/C.Tissue specificity; Skeletal muscle, heart, colon, testis, ovary ａnd pancreas.Function : Stabilizes ａnd promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding ａnd stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD ａnd BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF ａnd viral integrase. The association of viral DNA with chromatin requires the presence of BAF ａnd EMD. Required for proper localization of non-farnesylated prelamin-A/C.Subunit : Interacts with lamins A ａnd C, BANF1, GMCL, BCLAF1 ａnd YTHDC1/YT521. Interacts with TMEM43; the interaction retains emerin in the nuclear inner membrane. Interacts with SUN1 ａnd SUN2. Interacts with ACTB, SPTAN1, F-actin, CTNNB1 ａnd beta-tubulin.Subcellular Location : Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side. Nucleus outer membrane. Note=Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C （non-farnesylated or carboxymethylated farnesylated prelamin-A/C） in fibroblasts modify its localization in the nucleus.Tissue Specificity : Skeletal muscle, heart, colon, testis, ovary ａnd pancreas.Post-translational modifications : Found in four different phosphorylated forms, three of which appear to be associated with the cell cycle.DISEASE : Defects in EMD are the cause of Emery-Dreifuss muscular dystrophy type 1 （EDMD1） [MIM:310300]. A degenerative myopathy characterized by weakness ａnd atrophy of muscle without involvement of the nervous system, early contractures of the elbows Achilles tendons ａnd spine, ａnd cardiomyopathy associated with cardiac conduction defects.Similarity : Contains 1 LEM domain.Database links : UniProtKB/Swiss-Prot: P50402.1