本公司经销EDIL3，表皮生长因子样重复折叠1结构域蛋白3抗体，克隆类型为polyclonal，宿主来源是Rabbit，EDIL3表皮生长因子样重复折叠1结构域蛋白3抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-7029R
英文名称：Anti-EDIL3
中文名称：表皮生长因子样重复折叠1结构域蛋白3抗体
其他名称：名DEL1;Developmental endothelial locus 1;Developmentally regulated endothelial cell locus 1 protein;EGF like repeat ａnd discoidin I like domain containing protein 3;EGF like repeats ａnd discoidin I like domains protein 3;Integrin binding protein DEL1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 54kDa
纯化方法：affinity purified by Protein A
交叉反应：human, Mouse, Xenopus laevis, Zebrafish
产品介绍：EDIL3 is an integrin ligand. It plays an important role in mediating angiogenesis ａnd may be important in vessel wall remodeling ａnd development. It also influences endothelial cell behavior.EGF-like repeat ａnd discoidin I-like domain-containing protein 3 （EDIL3; also Del-1 ａnd integrin-binding DEL1） is a 52 kDa extracellular matrix protein that is expressed by endothelial tissues during embryonic vascular development. Human EDIL3 is synthesized as a precursor with a 16 amino acid （aa） signal sequence ａnd a 464 aa mature chain （SwissProt # O43854）. The mature chain is composed of three epidermal growth factor （EGF） repeats ａnd two discoidin-I-like domains. The second EGF repeat contains an RGD motif. Splicing variants produce two isoforms for human EDIL3. Isoform 2 has an A -> G substitution at aa 66 ａnd a deletion of aa 67-76 found in isoform 1. Mature human EDIL3 shares 96% aa sequence identity with mature mouse EDIL3. The RGD motif of EDIL3 binds alpha v beta 5 integrin, which, in turn, leads to increased angiogenic transcription factor HoxD3 expression. HoxD3 activates alpha v beta 3 ａnd uPA, resulting in the transformation of resting endothelial cells to an angiogenic state. EDIL3 becomes quiescent at the time of birth, ａnd is no longer expressed in normal adult tissues. It has been found, however, re-expressed in a number of human tumors as well as in ischemic muscles ａnd ischemic brain tissue, which may play an important role in adult angiogenesis. EDIL3 promotes adherence ａnd migration of endothelial cells, ａnd acts as an endothelial cell survival agent through upregulation of Bcl-2 expression. Exogenous application of EDIL3 has been demonstrated to augment angiogenesis ａnd improve blood flow ａnd tissue function in murine models of hind-limb ischemia, cardiac ischemia ａnd cerebral ischemia. EDIL3 has also been shown to be an endogenous inhibitor of inflammatory cell recruitment by interfering with the integrin LFA-1-dependent leukocyte-endothelial adhesion.