本公司经销ELAVL4/HuD，ELAVL4蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，ELAVL4/HuDELAVL4蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-11319R
英文名称：Anti-ELAVL4/HuD
中文名称：ELAVL4蛋白抗体
其他名称：名ELAV （embryonic lethal abnormal vision Drosophila） like 4;ELAV L4;ELAV like 4;ELAV like protein 4;ELAV-like protein 4;ELAV4_HUMAN;Elavl4;Embryonic lethal abnormal vision Drosophila homolog of like 4;Hu antigen D;Hu-antigen D;HuD;Paraneoplastic encephalomyelitis antigen HuD;PNEM.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 42kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, cow, Rb, Horse
产品介绍：The Elav-like genes encode for a family of RNA-binding proteins. Elav, a Drosophila protein ａnd the first described member, is expressed immediately after neuroblastic differentiation into neurons ａnd is necessary for neuronal differentiation ａnd maintenance. Several mammalian Elav-like proteins, designated HuC, HuD ａnd Hel-N1, are also expressed in postmitotic neurons. An additional mammalian homolog, HuR, which is also designated HuA, is ubiquitously expressed ａnd is also overexpressed in a wide variety of tumors. Characteristically, these homologs all contain three RNA recognition motifs （RRM） ａnd they specifically bind to AU-rich elements （ARE） in the 3＇-untranslated region of mRNAs transcripts. ARE sites target mRNA for rapid degradation ａnd thereby regulate the expression levels of genes involved in cell growth ａnd differentiation. When Elav-like proteins associate with these ARE sites this degradation is inhibited, leading to an increased stability of the corresponding transcript. Elav proteins function within the nucleus, ａnd they are shuttled between the nucleus ａnd cytoplasm by a nuclear export signal, which is a regulatory feature of the Elav-like proteins as it limits their accessibility to ARE sites.Function : May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3＇-UTR （By similarity）. Binds to AU-rich sequences （AREs） of target mRNAs, including VEGF ａnd FOS mRNA.Tissue Specificity : Brain.Post-translational modifications : Methylation at Arg-243 by CARM1 weakens protective binding to the 3＇-UTR of CDKN1A mRNA ａnd down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state. Methylation is inhibited by NGF, which facilitates neurite outgrowth.Similarity : Belongs to the RRM elav family.Contains 3 RRM （RNA recognition motif） domains.