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eIF2 alpha真核启动因子2α抗体(eIFα2)
点击次数：1000发布时间：2012/12/5 16:29:35
更新日期：2024/9/5 14:43:14
所 在 地：中国大陆
产品型号：BY-3613R
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货号：BY-3613R
英文名称：Anti-eIF2 alpha
中文名称：真核启动因子2α抗体（eIFα2）
其他名称：名 CDA 02; CDA02; eIF 2 alpha; EIF 2; EIF 2A; EIF-2alpha; EIF2; EIF2A; EIF2alpha; eIF2S1; Eukaryotic Translation Initiation Factor 2 alpha; Eukaryotic translation initiation factor 2 subunit 1 alpha 35kDa; Eukaryotic translation initiation factor 2 subunit alpha.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 65kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb, bow, chk
产品介绍：eIF2 alpha is a 36 kDa protein which is ubiquitously expressed in many cell types. The eIF2 protein, which is composed of three subunits （alpha, beta ａnd gamma）, is one of the key molecules in the initiation of translation. In mammalian cells, eIF2 alpha is phosphorylated at serine 51 （human EIF2 alpha, the equivalent residue in mouse is serine 52） by at least two kinases: the haem-controlled repressor （HCR） ａnd the interferon inducible double stranded RNA-dependent protein kinase （PKR）. Phosphorylation of eIF2 alpha blocks the GDP-GTP exchange activity of eIF2 beta, resulting in the suppression of protein synthesis. The phosphorylation of eIF2 alpha is an important regulatory process in protein synthesis.Subunit : Heterotrimer composed of an alpha, a beta ａnd a gamma chain. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 ａnd HSPA5. Interaction with METAP2 protects EIF2S1 from inhibitory phosphorylation （By similarity）. Interacts with ABCF1 isoform 2. Associates with ribosomes.Subcellular Location : Cytoplasmic granule.Similarity : Belongs to the eIF-2-alpha family.Contains 1 S1 motif domain.eIF2α（真核启动因子2α）
