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Anti-ABCA7三磷酸腺苷结合盒转运蛋白7抗体
点击次数：186发布时间：2012/12/26 1:42:56
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-11180R
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详细内容
货号：BY-11180R
英文名称：Anti-ABCA7
中文名称：三磷酸腺苷结合盒转运蛋白7抗体
其他名称：ABC transporter ABCA7;ABC transporter member 7;ABCA SSN;ABCX;ATP binding cassette sub family A （ABC1） member 7;ATP binding cassette sub family A member 7;ATP binding Cassette Transporter A7;,FLJ40025;Macrophage ABC transporter.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 237kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：ATP-binding cassette （ABC） transporters are an evolutionarily conserved family of widely-expressed proteins that use ATP hydrolysis to catalyze the transport of various molecules across extracellular ａnd intracellular membranes. Eukaryotic ABC transporters are largely responsible for trafficking hydrophobic compounds either within the cell as part of a metabolic process, outside the cell for transport to other organs, or for secretion from the body. The cholesterol-responsive transporter, ABCA7, maps to human chromosome 19 ａnd mouse chromosome 10 ａnd has been reported as a candidate regulator of ceramide transport in epidermal lipid reorganization. High expression levels of ABCA7 have been reported in myelolymphatic tissues, reticuloendothelial cells, peripheral leukocytes, thymus, spleen ａnd bone marrow. This expression pattern of the two alternatively-spliced isoforms also indicates an involvement in lipid homeostasis in cells of the immune system, though the complete role of ABCA7 is not yet known. Full-length type I ABCA7 has shown plasma membrane localization, while the type II splicing variant has shown expression predominantly in the endoplasmic reticulum.Subcellular Location : Cell Membrane ａnd Cytoplasmic
