本公司经销Na+/K+-ATPase Alpha1，Na+/K+-ATPase α1 钠钾ATP酶α1抗体，克隆类型为polyclonal，宿主来源是Rabbit，Na+/K+-ATPase Alpha1Na+/K+-ATPase α1 钠钾ATP酶α1抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-9570R
英文名称：Anti-Na+/K+-ATPase Alpha1
中文名称：Na+/K+-ATPase α1 钠钾ATP酶α1抗体
其他名称：AT1A1_HUMAN; ATP1A1; Atpa-1; ATPase Na+/K+ transporting alpha 1 polypeptide; BC010319; EC 3.6.3.9; MGC3285; MGC38419; MGC51750; Na K ATPase alpha A catalytic polypeptide; Na K ATPase catalytic subunit alpha A protein; Na（+）/K（+） ATPase 1; Na（+）/K（+） ATPase alpha-1 subunit; Na+/K+ ATPase alpha 1 subunit; Na+/K+ ATPase 1; Nkaa1b; Sodium potassium ATPase alpha 1 polypeptide; Sodium pump 1; Sodium pump subunit alpha-1; Sodium/potassium transporting ATPase alpha 1 chain; Sodium/potassium-transporting ATPase subunit alpha-1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 112kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, chk, pig, dog, Rb
产品介绍：The ubiquitously expressed sodium/potassium-ATPase （Na+/K+-ATPase） exists as a oligomeric plasma membrane complex that couples the hydrolysis of one molecule of ATP to the importation of three Na+ ions ａnd two K+ ions against their respective electrochemical gradients. As a member of the P-type family of ion motives, Na+/K+-ATPase plays a critical role in maintaining cellular volume, resting membrane potential ａnd Na+-coupled solute transport.The Alpha subunit contains the binding sites for ATP ａnd the cations; the glycosylated Beta subunit ensures correct folding ａnd membrane insertion of the Alpha subunits. The small subunit co-localizes with the Alpha subunit in nephron segments, where it increases the affinity of Na+/K+-ATPase for ATP. The Betasubunit, but not the subunit, is essential for normal activity of Na+/K+-ATPase.Function : This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium ａnd potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium ａnd potassium ions, providing the energy for active transport of various nutrients.Subunit : Interacts with SIK1. Composed of three subunits: alpha （catalytic）, beta ａnd gamma. Binds the HLA class II histocompatibility antigen, DR1. Subcellular Location : Cell membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.Post-translational modifications : Phosphorylation on Tyr-10 modulates pumping activity. Dephosphorylation by protein phosphatase 2A （PP2A） following increases in intracellular sodium, leading to increase catalytic activitySimilarity : Belongs to the cation transport ATPase （P-type） （TC 3.A.3） family. Type IIC subfamily.