本公司经销AACT-Alpha1/A1ACT，α-1抗胰糜蛋白酶抗体，克隆类型为polyclonal，宿主来源是Rabbit，AACT-Alpha1/A1ACTα-1抗胰糜蛋白酶抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0094R
英文名称：Anti-AACT-Alpha1/A1ACT
中文名称：α-1抗胰糜蛋白酶抗体
其他名称：Alpha-1-Antichymotrypsin; SERPINA3; AACT; ACT; Alpha 1 Antichymotrypsin 1; Alpha 1 Antichymotrypsin 2; Alpha 1 Antichymotrypsin 3; Alpha 1 Antitrypsin Deficiency; Anti Elastase; Antichymotrypsin; Cell growth inhibiting gene 24/25 protein; Clade A （Alpha 1 Antiproteinase Antitrypsin）; GIG24; GIG25; Growth inhibiting protein 24; Growth inhibiting protein 25; MGC88254; PI1; Protease Inhibitor 1; Serine （or Cysteine） Proteinase Inhibitor; Serine （or cysteine） proteinase inhibitor clade A （alpha 1 antiproteinase, antitrypsin） member 3; Serine （or cysteine） proteinase inhibitor clade A member 3; Serine proteinase inhibitor clade A member 3; Serpin peptidase inhibitor clade A （alpha 1 antiproteinase antitrypsin） member 3; SERPINA1; SERPINA2; SERPINA3.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 45kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
产品介绍：Alpha 1-Antichymotrypsin, a member of the serine proteinase inhibitor （serpin） family, inhibits neutrophil proteinase cathepsin G ａnd mast cell chymases, ａnd protects the lower respiratory tract from damage by proteolytic enzymes. It contains a reactive centre loop, which interacts with cognate proteinases, resulting in loop cleavage ａnd a major conformational change. Recently, alpha 1-antichymotrypsin has been identified as a major constituent of the neurofibrillary plaques associated with Alzheimers disease, ａnd in vitro studies have shown that it enhances the rate of amyloid-fibril formation. These observations ａnd recent genetic evidence suggest that alpha 1-antichymotrypsin is important in the pathogenesis of Alzheimers disease. Function : Although its physiological function is unclear, it can inhibit neutrophil cathepsin G ａnd mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.Subunit : Interacts with DNAJC1.Subcellular Location : Secreted.Tissue Specificity : Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.Similarity : Belongs to the serpin family.AACT是由神经胶质细胞分泌并参与淀粉样纤维生成和沉积的一种色氨酸蛋白酶抑制剂,被认为是Aβ肽的假性底物，与Aβ肽具有很高的亲合性，可促进Aβ肽的纤维化以生成淀粉样沉积。ApoE作为AD的另一种病理伴随性物质，也可识别并与Aβ肽相结合，促进Aβ肽沉积生成淀粉样老年斑块。由于AACT和ApoE在AD发病中具有共同的作用途径，因此探讨其相互作用可能是AD治疗中一个新的途径。 AACT是一种丝氨酸蛋白酶抑制剂，可以中和糜蛋白酶等酶活性的蛋白酶，存在于大多数的组织细胞、巨噬细胞以及多种胃肠道和肺部肿瘤中，但多形核白细胞中无此物质，它可以作为组织细胞瘤和良性/恶性纤维组织细胞瘤的标志。此抗体与人的AACT反应，主要用于恶性纤维组织细胞瘤等恶性肿瘤的诊断,也可用于胃癌﹑肺癌、肾癌等肿瘤的研究。