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Anti-ARRDC3抑制蛋白结构域蛋白3抗体
点击次数：194发布时间：2012/12/26 1:59:36
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-8077R
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货号：BY-8077R
英文名称：Anti-ARRDC3
中文名称：抑制蛋白结构域蛋白3抗体
其他名称：ARRDC 3; Arrestin domain containing protein 3; KIAA1376; Thioredoxin binding protein 2 like inducible membrane; TLIMP.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 46kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, hrs, chk, cow, dog, Rb
产品介绍：The arrestins are a family of proteins that are important for regulating signal transduction within cells. Arrestins are part of a conserved two step mechanism for regulating the activity of G-protein coupled receptors （GPCRs）. In response to a stimulus, GPCRs activate a heterotrimeric G protein. In order to turn off this response, or adapt to a constant stimulus, activated receptors need to be silenced. The first step is phosphorylation by a class of serine/threonine kinases called G protein coupled receptor kinases （GRKs）. This phosphorylation specifically marks the activated receptor for arrestin binding. Once arrestin is bound to the receptor it is unable to signal further. Recent research continues to expand the known actions of arrestins, which can bind to other classes of receptors ａnd can directly activate signaling pathways on their own. Different arrestins （visual arrestin （or Arrestin 1）, beta-arrestin 1 （or Arrestin 2） ａnd beta-arrestin 2 （or Arrestin 3） can reduce the activity of their target GPCRs in several different ways.Subcellular Location : Cytoplasm. Tissue Specificity : Highly expressed in skeletal muscle, placenta, kidney, adrenal gland, lymph node, mammary gland, thyroid, ａnd trachea. Very low levels in colon, thymus, spleen, small intestine, bladder ａnd bone marrow. Strong expression in differentiated adipocytes compared to preadipocytes.Similarity : Belongs to the arrestin family.
