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Anti-ANKS1B/AIDA1β淀粉样蛋白胞内结构域相关蛋白1抗体
点击次数：278发布时间：2012/12/26 2:02:07
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-9097R
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货号：BY-9097R
英文名称：Anti-ANKS1B/AIDA1
中文名称：β淀粉样蛋白胞内结构域相关蛋白1抗体
其他名称：AIDA 1;AIDA-1;Amyloid-beta protein intracellular domain-associated protein 1;Anks1b;Ankyrin repeat ａnd sterile alpha motif domain-containing protein 1B;ANS1B_HUMAN;E2A-PBX1-associated protein;EB-1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 138kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：The β-Amyloid protein precursor （AbPP） is a widely expressed transmembrane protein that is processed into the b-Amyloid （Ab） peptide, which accumulates in insoluble plaques in the brain of Alzheimer’s disease patients ａnd AbPP intracellular domain （AID）. AID may function as a pro-apoptotic peptide, a regulator of calcium homeostasis ａnd a molecule involved in transcriptional regulation. The AID associated protein 1 （AIDA-1） is highly expressed in the brain ａnd is regulated by AbPP. It interacts with AbPP to play a role in brain development. AIDA-1 also interacts with coilin in Cajal bodies to regulate pre-mRNA splicing.Subcellular Location : Cytoplasm; Nucleus; Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell projection > dendritic spine. Nucleus. Nucleus > Cajal body. The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors （NMDARs） in a calcium-independent manner ａnd Nucleus. The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.Tissue Specificity : Highly expressed in marrow from patients with pre-B ALL associated with the t（1;19） translocation. Strongly expressed in brain ａnd testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain （at protein level）. Isoform 6 is expressed in brain ａnd several cancer cell lines.
