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Anti-AAT1/C3orf153号染色体开放阅读框15抗体
点击次数：338发布时间：2012/12/26 2:04:37
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-9823R
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货号：BY-9823R
英文名称：Anti-AAT1/C3orf15
中文名称：3号染色体开放阅读框15抗体
其他名称：AAT 1;AAT-1;AAT1;AAT1 alpha;AAT1_HUMAN;AAT1alpha;AMY 1 associating protein expressed in testis 1;AMY-1-associating protein expressed in testis 1;Chromosome 3 open reading frame 15;MYCBP binding protein.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 71kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：The c-Myc proto-oncogene plays a significant role in cell proliferation, differentiation, transformation ａnd apoptosis. A novel c-Myc binding protein, MYCBP （also designated AMY-1）, binds to the transactivation domain of c-Myc ａnd stimulates the activation of E-box-dependent transcription. MYCBP translocates from the cytoplasm to the nucleus during S phase when increased expression of c-Myc occurs. MYCBP ａnd AAT-1 （AMY-1-associating protein expressed in testis 1） have been shown to associate with AKAP 149 ａnd AKAP 84 in mitochondria of somatic cells ａnd sperm, which suggests a role for MYCBP ａnd AAT-1 in spermatogenesis. Expression of the AAT-1 gene is regulated by two different promoters, which result in various isoforms. One promoter generates expression of the AAT-1, AAT-1å, AAT-1∫ ａnd AAT-1© isoforms, which are specifically expressed in testis, while the other promoter generates AAT-1L, AAT-1M ａnd AAT-1S, which are differentially expressed.Subcellular Location : Cytoplasm. Mitochondrion. Isoform 4 is found in the mitochondria ａnd localized in the neck of the sperm.Tissue Specificity : Isoform 1 is strongly expressed in the liver. Isoform 4 is widely expressed, but strongly expressed in all spermatogenesis-related tissues, including the testis, the epithelium of cauda ａnd the corpus epididymis. Isoform 4 is present in the spermatid ａnd mature sperm. Isoform 4 is also expressed in Leydig cells. Isoform 3 is expressed in the testis.
