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Anti-ApoB/Apolipoprotein B载脂蛋白B抗体
点击次数：258发布时间：2012/12/26 2:05:31
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-6333R
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详细内容
货号：BY-6333R
英文名称：Anti-ApoB/Apolipoprotein B
中文名称：载脂蛋白B抗体
其他名称：Apo B 100; Apo B; Apo B-100; Apo B-48; ApoB 100; ApoB 48; ApoB; APOB protein; APOB_HUMAN; Apolipoprotein B 100; Apolipoprotein B 48; Apolipoprotein B; Apolipoprotein B-48; FLDB.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 549kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, hrs, Rb
产品介绍：Apolipoprotein B is a major protein constituent of chylomicrons （apo B-48）, LDL （apo B-100） ａnd VLDL （apo B-100）. Apo B-100 functions as a recognition signal for the cellular binding ａnd internalization of LDL particles by the apoB/E receptor.Involvement in disease: Defects in APOB are a cause of hypobetalipoproteinemia familial type 1 （FHBL1） . A disorder characterized by highly reduced plasma concentrations of low density lipoproteins, ａnd dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal ａnd neurological dysfunction similar to abetalipoproteinemia.Defects in APOB are a cause of familial ligand-defective apolipoprotein B-100 （FDB）. FDB is a dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia ａnd increased proneness to coronary artery disease （CAD）. The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors.Subcellular Location : Secreted.Similarity : Contains 1 vitellogenin domain.
