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Anti-ADNP/NAP活性依赖的神经保护肽抗体
点击次数：212发布时间：2012/12/26 2:13:14
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-0039R
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货号：BY-0039R
英文名称：Anti-ADNP/NAP
中文名称：活性依赖的神经保护肽抗体
其他名称：Activity dependent neuroprotective protein; Activity dependent neuroprotector; ADNP; KIAA0784
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 114kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, cow, chk
产品介绍：The activity dependent neuroprotective protein （ADNP） gene is frequently amplified in many neoplasias, including breast, bladder, ovarian, pancreatic, ａnd colon cancers. ADNP mRNA is abundantly expressed in distinct normal tissues, ａnd high expression levels were encountered in malignant cells. ADNP is implicated in maintaining cell survival, perhaps through modulation of p53. The encoded protein contains one homeobox ａnd nine zinc finger domains, suggesting that it functions as a transcription factor. Function : Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth ａnd cancer proliferation.Subcellular Location : Nucleus （Potential）.Tissue Specificity : Widely expressed. Strong expression in heart, skeletal muscle, kidney ａnd placenta. In brain, expression is stronger in the cerebellum ａnd cortex regions. No expression detected in the colon. Strong increase of expression in colon ａnd breast cancer tissues.Similarity : Contains 9 C2H2-type zinc fingers. Contains 1 homeobox DNA-binding domain.是一个潜在的转录调节因子，参与正常细胞与肿瘤细胞的增殖调控。广泛分布于大脑、小脑等组织，在肺、肾、小肠以及睾丸等组织也有微弱的表达。对体外培养的glia缺失神经元细胞有保护作用.
