本公司经销Drebrin，脑发育调节蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，Drebrin脑发育调节蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-5835R
英文名称：Anti-Drebrin
中文名称：脑发育调节蛋白抗体
其他名称：DBN 1; DBN1; Developmentally regulated brain protein; Drebrin 1; Drebrin E; Drebrin1; DrebrinE; D0S117E.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 72kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, hrs, pig, cow, Rb, chk
产品介绍：Drebrin is a major neuronal F-actin binding protein involved in the control of actin dynamics ａnd neuronal morphogenesis. Three major isoforms of drebrin, resulting from alternative splicing of a single gene, have been identified in the brain: the embryonic isoforms designated E1 ａnd E2 ａnd the adult or A isoform （95-120 kDa）. An additional truncated form of drebrin A, s-drebrin/A2 （42 kDa）, is specifically expressed in the adult brain, but not in non-neuronal tissues. Drebrin is also widely expressed in a variety of cells including epithelial, endothelial, ａnd smooth muscle cells ａnd is associated at cell-cell adhering junction sites.Drebrin is thought to play a central role in the formation of axons ａnd dendrites during neuronal development ａnd in neuronal plasticity in the adult brain. The expression of each drebrin isoform is regulated throughout distinct phases in neuronal development. The earliest embryonic form E1, is thought to function in migration, while the E2 isoform, which replaces E1 during embryogenesis, is believed to play a role in migration as well as formation of axons ａnd dendrites. Drebrin E2 is present at low levels in the adult brain. The drebrin A isoform, which is only present in mature neurons, is assumed to be involved in synaptic plasticity. Drebrin E2 ａnd A isoforms are targeted to different regions of actin localization. In neurons, the E2 isoform localizes to the submembrane region, while the A isoform is specifically located ａnd evenly distributed throughout the post-synaptic dendritic spine.Function : Drebrins might play some role in cell migration, extension of neuronal processes ａnd plasticity of dendrites, respectively.Subunit : Contains 1 ADF-H domain.Subcellular Location : Cytoplasm.Tissue Specificity : Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney ａnd pancreas.