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Anti-ATX2脊髓小脑共济失调2型蛋白抗体
点击次数：230发布时间：2012/12/26 2:34:40
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-7974R
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货号：BY-7974R
英文名称：Anti-ATX2
中文名称：脊髓小脑共济失调2型蛋白抗体
其他名称：Ataxin 2; ATXN2; Olivopontocerebellar ataxia 2, autosomal dominant; SCA2; Spinocerebellar ataxia type 2 protein; TNRC13; Trinucleotide repeat containing gene 13 protein.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 144kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, pig, cow, hrs, chk
产品介绍：The autosomal dominant cerebellar ataxias （ADCA） are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem ａnd spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ATX2 belongs to the autosomal dominant cerebellar ataxias type I （ADCA I） which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar ａnd extrapyramidal signs, peripheral neuropathy ａnd dementia. ATX2 is caused by expansion of a CAG repeat in the coding region of ATX2. Longer expansions result in earlier onset of the disease. There are four named isoforms.Subunit : Monomer. Can also form homodimers.Subcellular Location : Cytoplasm.Tissue Specificity : Expressed in the brain, heart, liver, skeletal muscle, pancreas ａnd placenta. Isoform 1 is predominant in the brain ａnd spinal cord. Isoform 4 is more abundant in the cerebellum. In the brain, broadly expressed in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus ａnd thalamus.Similarity : Belongs to the ataxin-2 family.
