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Anti-AICDA活化诱导胞嘧啶核苷脱氨酶抗体
点击次数：283发布时间：2012/12/26 2:40:24
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-7855R
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货号：BY-7855R
英文名称：Anti-AICDA
中文名称：活化诱导胞嘧啶核苷脱氨酶抗体
其他名称：Activation induced cytidine deaminase; Activation induced deaminase; Activation-induced cytidine deaminase; AICDA; AICDA_HUMAN; AID; ARP 2; ARP2; CDA 2; CDA2; Cytidine aminohydrolase; HIGM2; Integrated into Burkitt＇s lymphoma cell line Ramos.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 24kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, hrs, Rb
产品介绍：RNA-editing deaminase involved in somatic hypermutation, gene conversion, ａnd class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses.Tissue specificity:Strongly expressed in lymph nodes ａnd tonsils.Involvement in disease:Defects in AICDA are the cause of hyper-IgM immunodeficiency syndrome type 2 （HIGM2）; also known as hyper-IgM syndrome 2. HIGM2 is an autosomal recessive disorder characterized by normal or elevated serum IgM levels with absence of IgG, IgA, ａnd IgE, resulting in a profound susceptibility to bacterial infections. HIGM2 causes the absence of Ig class switch recombination （CSR）, the lack of Ig somatic hypermutations, ａnd lymph node hyperplasia caused by the presence of giant germinal centers.Tissue Specificity : Strongly expressed in lymph nodes ａnd tonsils.Similarity : Belongs to the cytidine ａnd deoxycytidylate deaminase family.
