本公司经销ARF6，ADP核糖基化因子6抗体，克隆类型为polyclonal，宿主来源是Rabbit，ARF6ADP核糖基化因子6抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1145R
英文名称：Anti-ARF6
中文名称：ADP核糖基化因子6抗体
其他名称：ADP-ribosylation factor 6; Small GTPase; AI788669; AW496366; MGC102530; ADP ribosylation factor protein 6; DKFZp564M0264; Small GTP binding protein.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 19kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb, hrs, pig, chk
产品介绍：This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin ａnd play a role in vesicular trafficking ａnd as activators of phospholipase D. The product of this gene is localized to the plasma membrane, ａnd regulates vesicular trafficking, remodelling of membrane lipids, ａnd signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7.Function : GTP-binding protein involved in protein trafficking; regulates endocytic recycling ａnd cytoskeleton remodeling. May modulate vesicle budding ａnd uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development. Contributes to the regulation of dendritic branching ａnd filopodia extension.Subunit : Interacts with ARHGAP21, ASAP2, HERC1, PIP5K1C ａnd UACA. Interacts with NCS1/FREQ at the plasma membrane. Interacts with RAB11FIP3 ａnd RAB11FIP4. Interacts with USP6 （via Rab-GAP TBC domain）. Interacts with ECM29. Interacts with TBC1D24.Subcellular Location : Golgi apparatus. Cell membrane; Lipid-anchor. Endosome membrane; Lipid-anchor. Cell membrane. Cell projection, filopodium membrane; Lipid-anchor. Note=Recruited to the cell membrane in association with CYTH2 ａnd ARL4C.Similarity : Belongs to the small GTPase superfamily. Arf family.ARF6主要用于：肿瘤方面的研究，在很多肿瘤组织中都有一定的表达及分布。 技术背景：rRNA 加工、内质网高尔基膜泡介导运输、细胞运动性、细胞附着、小GTP 酶介导信号转导、蛋白运输、膜泡介导运输、正调控肌动蛋白丝聚合、皮层肌动蛋白细胞骨架组织和生物发生、褶边组织和生物发生、调控Rac 蛋白信号转导、负调控受体介导胞吞.