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Anti-ArteminArtemin抗体
点击次数:224发布时间:2012/12/26 2:45:08
更新日期:2024/9/5 14:43:27
所 在 地:其它
产品型号:BY-0055R
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货号:BY-0055R
英文名称:Anti-Artemin
中文名称:Artemin抗体
其他名称:Artemin; ARTN; Enovin; EVN; NBN; Neublastin
抗体来源:Rabbit
克隆类型:polyclonal
蛋白分子量:predicted molecular weight: 12kDa
纯化方法:affinity purified by Protein A
交叉反应:mo, rat, hu
产品介绍:Artemin is a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFR alpha3-RET receptor complex. The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenrative disease. Artemin has been shown in culture to support the survival of a number of periferal neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Four alternatively spliced transcripts have been described, two of which encode the same protein. Function : Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity).Subunit : Homodimer; disulfide-linked. Binds to RET (By similarity).Subcellular Location : Secreted (By similarity).Tissue Specificity : Cochlea. Expressed at higher level in sesorineural epithelium than in the modiolus region or substantia nigra.Similarity : Belongs to the TGF-beta family. GDNF subfamily.神经生物学相关蛋白(Neurobiology)Artemin 是GDNF 家族的一个新成员,已被证实它是从前的孤儿受体GFRalpha3-RET的配体。 Artemin是感觉和交感神经元培养的一个存活因子,它的表达形式也影响体内的这些神经元。Artemin 还能激活GFRalpha1-RET 复合物并支持培养中脑多巴胺神经元存活。产品图片Antigen: bs-0055P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG(bs-0295G-HRP) at 1: 5000; TMB(C-0024) staining; Read the data in MicroplateReader by 450nm.