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Anti-APPL1衔接因子蛋白含pH域磷酸酪氨酸结合域和亮氨酸拉链蛋白1抗体
点击次数：273发布时间：2012/12/26 2:47:33
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-1632R
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货号：BY-1632R
英文名称：Anti-APPL1
中文名称：衔接因子蛋白含pH域磷酸酪氨酸结合域和亮氨酸拉链蛋白1抗体
其他名称：Adaptor Protein Containing pH Domain; Adaptor protein containing pH domain PTB domain ａnd leucine zipper motif 1; Adaptor protein containing pH domain PTB domain ａnd leucine zipper motif; AKT2 INTERACTOR; APPL 1; APPL1; DCC interacting protein 13 alpha; DIP 13 alpha; DIP13 alpha; DIP13alpha; KIAA1428; PTB domain ａnd leucine zipper motif 1; PTB Domain ａnd Leucine Zipper Motif; Signaling adaptor protein DIP13alpha.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 78kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, Rb, cow, dog, hrs
产品介绍：APPL is involved in the regulation of cell proliferation, ａnd in the crosstalk between the adiponectin signalling ａnd insulin signalling pathways.The APPL binds to RAB5A/Rab5 through N terminal domain. This interaction is essential for its recruitment to endosomal membranes as well as its role in cell proliferation.Subcellular Location : Early endosome membrane; Peripheral membrane protein. Nucleus. Note=Early endosomal membrane-bound ａnd nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.Tissue Specificity : High levels in heart, ovary, pancreas ａnd skeletal muscle.Similarity : Contains 1 PH domain.Contains 1 PID domain.衔接因子蛋白含pH域磷酸酪氨酸结合域和亮氨酸拉链基元1抗体.APPL1可调节脂联素和胰岛素信号，是细胞膜与细胞核之间重要的信息传递蛋白,同时也是细胞增殖所必需的蛋白，它有调节脂联素在脂肪酸氧化和葡萄糖吸收中的作用，APPL1通过激酶通道来调节脂联素的胰岛素敏感效应。
