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Anti-Apollon/BIRC6Apollon凋亡抑制蛋白抗体
点击次数：284发布时间：2012/12/26 2:51:17
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-1489R
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货号：BY-1489R
英文名称：Anti-Apollon/BIRC6
中文名称：Apollon凋亡抑制蛋白抗体
其他名称：BIRC6; Apollon; Apollon protein; Baculoviral IAP repeat containing 6; Baculoviral IAP repeat containing protein 6; BIRC 6; BRUCE; FLJ13726; FLJ13786; KIAA1289; Ubiquitin conjugating BIR domain enzyme apollon.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 528kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, cow, hrs, Rb
产品介绍：Conserved genes that encode inhibitors of apoptosis proteins （IAPs） are frequently overexpressed in human cancers ａnd are associated with resistance to therapy. IAPs contain a 70 amino acid cysteine ａnd histidine rich baculovirus IAP repeat （BIR） ａnd often a zinc binding RING finger. Chen et al. （1999） found that some brain cancer cell lines with high expression of BIRC6 exhibited resistance to apoptosis in the presence of anticancer drugs. Treatment of a high expressing cell line with BIRC6 antisense oligonucleotides reduced BIRC6 expression ａnd reversed the resistance to anticancer drugs.Apollon是凋亡抑制蛋白家族IAP（inhibitors of apoptosis protein 凋亡抑制因子）的成员，它通过抑制Smac和caspase-9酶活性而产生抗凋亡作用它是IAP家族中分子量的成员,Apollon在某些肿瘤组织中表达。
