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Anti-Alpha-Catenin/CTNNA1α-连环蛋白抗体（钙粘蛋白相关蛋白）Catenin α
点击次数：211发布时间：2012/12/26 2:51:44
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-1594R
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货号：BY-1594R
英文名称：Anti-Alpha-Catenin/CTNNA1
中文名称：α-连环蛋白抗体（钙粘蛋白相关蛋白）Catenin α
其他名称：alpha catenin; alpha E catenin; alphaE catenin; Cadherin associated protein 102kDa; Cadherin associated protein; CAP 102; CAP102; Catenin （cadherin associated protein） alpha 1 102kDa; Catenin alpha 1; CTNNA 1; CTNNA1; Alpha-cats; FLJ36832; NY REN 13 antigen.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 102kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, hrs, Rb, dog, chk
产品介绍：The distinct peripheral cytosolic proteins, alpha, beta ａnd gamma-catenin （102, 94 ａnd 86 kDa） found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins ａnd are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines ａnd reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin ａnd interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.细胞粘附蛋白（Call Adhesion Protein）α-catenin是一种多功能的蛋白质，能链接E-\\N-\\P-钙粘附分子,具有参与细胞粘附和介导信号转导的双重功能，并与肿瘤的发生发展及浸润密切相关。在正常个体中，βα-catenin和钙黏蛋白形成复合体，介导同型细胞的粘附，维持细胞的稳定；同时，α-catenin作为Wnt/α-catenin信号通路的关键成员在介导信号转导过程中调控细胞的增殖和凋亡。在恶性肿瘤中，α连环蛋白的表达呈现明显的异质性，促使细胞异常增殖，还可使细胞之间的黏附性减弱，侵袭性增强。
