本公司经销beta Adaptin/AP2，衔接蛋白β抗体，克隆类型为polyclonal，宿主来源是Rabbit，beta Adaptin/AP2衔接蛋白β抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1546R
英文名称：Anti-beta Adaptin/AP2
中文名称：衔接蛋白β抗体
其他名称：名Adaptin beta 1 （beta prime）; β-Adaptin; Adaptin β1; Adaptin-β1; Adaptin beta 2 （beta）; Adaptin beta 2; Adaptin, beta 2 （beta）; Adaptor protein complex AP 1 beta 1 subunit; Adaptor related protein complex 1 beta 1 subunit; Adaptor related protein complex 1, beta 1 subunit; Adaptor related protein complex 2 beta 1 subunit; Adaptor related protein complex 2, beta 1 subunit; ADTB 1; ADTB 2; ADTB1; ADTB2; AP 1 complex subunit beta 1; AP 105A; AP 105B; AP 2 complex subunit beta 1; AP1 Beta; AP1 complex subunit beta 1; AP105A; AP105B; AP1B1; AP2 beta; AP2 complex subunit beta 1; AP2B1; AP2beta; BAM 22; BAM22; Beta adaptin; Beta prime adaptin; Beta1 adaptin; Beta2 adaptin; CLAPB 1; CLAPB 2; CLAPB1; CLAPB2; Clathrin assembly protein complex 1; Clathrin assembly protein complex 1 beta large chain; Clathrin assembly protein complex 2 beta large chain; Clathrin associated/assembly/adaptor protein large beta 1; Clathrin associated/assembly/adaptor protein large beta 2; DKFZp781K0743; Golgi adaptor HA1/AP1 adaptin beta subunit; Plasma membrane adaptor HA2/AP2 adaptin beta subunit; Plasma membrane adaptor HA2/AP2 adaptor beta subunit; Plasma membrane adaptor HA2/AP2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 103kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, pig, dog, hrs, Rb
产品介绍：Sequence-specific DNA-binding protein that interacts with inducible viral ａnd cellular enhancer elements to regulate transcription of selected genes. AP2 factors bind to the consensus sequence 5＇-GCCNNNGGC-3＇ ａnd activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs ａnd neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha ａnd MYC. AP2 beta appears to be required for normal face ａnd limb development ａnd for proper terminal differentiation ａnd function of renal tubular epithelia.Function : Component of the adaptor protein complex 2 （AP-2）. Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components ａnd appear to be involved in cargo selection ａnd vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrrounded by clathrin （clathrin-coated vesicles, CCVs） which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein （AP） complexes which can bind directly to both the clathrin lattice ａnd to the lipid ａnd protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] （Y-X-X-Phi） ａnd [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins （CLASPs） are recognized by their [DE]-X（1,2）-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly.Subunit : Adaptor protein complex 2 （AP-2） is an heterotetramer composed of two large adaptins （alpha-type subunit AP2A1 or AP2A2 ａnd beta-type subunit AP2B1）, a medium adaptin （mu-type subunit AP2M1） ａnd a small adaptin （sigma-type subunit AP2S1）. Interacts with EPN1. Interacts with EPS15; clathrin competes with EPS15. Interacts with SNAP91; clathrin competes with SNAP91. Interacts with CLTC; clathrin competes with EPS15, SNAP91 ａnd PIP5K1C. Interacts with LDLRAP1. Interacts with AMPH ａnd BIN1. Interacts with ARF6 （GDP-bound）. Interacts （dephosphorylated at Tyr-737） with ARRB1; phosphorylation of AP2B1 at Tyr-737 disrupts the interaction. Interacts with SLC2A8. Interacts with SCYL1 ａnd SCYL2. Interacts with TGFBR1 ａnd TGFBR2. Interacts with PIP5K1C; clathrin competes with PIP5K1C （By similarity）. Interacts with DENND1B, but not with DENND1A, nor DENND1C. Interacts with FCHO1.Subcellular Location : Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=AP-2 appears to be excluded from internalizing CCVs ａnd to disengage from sites of endocytosis seconds before internalization of the nascent CCV.Post-translational modifications : Phosphorylation at Tyr-737 by SRC occurs at the plasma membrane in clathrin-coated vesicles （CCVs）.Similarity : Belongs to the adaptor complexes large subunit family.Adaptin β蛋白参与披网格蛋白小泡组装的一种蛋白质, 在披网格蛋白小泡组装中与受体的细胞质结构域相互作用, 起衔接作用。